Stroke 106 items

Studies

• Lp(a) and the risk of CHD, stroke and non-vascular mortality: the Emerging Risk Factors Collaboration (JAMA 2009)JAMA · July 2009 9
• Lp(a) risk persists at the lowest achieved LDL-C: participant-level meta-analysis of six statin trials (Bhatia et al., Circulation 2025)Circulation · January 2025 8
• Inflammation, cholesterol, Lp(a) and 30-year cardiovascular outcomes in women (Ridker et al., NEJM 2024)N Engl J Med · December 2024 8
• Alirocumab-induced Lp(a) lowering independently predicts fewer MACE after ACS: ODYSSEY OUTCOMES (Bittner et al., JACC 2020)J Am Coll Cardiol · January 2020 8
• The phenotypic consequences of genetically lowered Lp(a) (Emdin et al., JACC 2016)J Am Coll Cardiol · December 2016 8
• First-degree relatives of people with elevated Lp(a) have more MACE: Swedish registry cohort (Kindborg et al., EHJ 2026)Eur Heart J · July 2026 7
• Lp(a) predicts coronary events but not stroke, and evolocumab benefits at any Lp(a): VESALIUS-CV (Monguillon et al., Circulation 2026)Circulation · June 2026 7
• Safety of low Lp(a): no excess of bleeding, malignancy, neurocognitive events or AF, but more diabetes: FOURIER (Gencer et al., EHJ 2026)Eur Heart J · June 2026 7
• Coronary artery calcium still stratifies risk in people with elevated Lp(a): a four-cohort study (Bhatia et al., JACC 2026)J Am Coll Cardiol · May 2026 7
• Thirty-year cardiovascular risk in healthy women by Lp(a) threshold: the Women's Health Study (Nordestgaard AT et al., JAMA Cardiol 2026)JAMA Cardiol · February 2026 7
• Lp(a) raises cardiovascular risk regardless of hs-CRP, in primary and secondary prevention (Small et al., JAMA Cardiol 2024)JAMA Cardiol · April 2024 7
• Lp(a) levels in a global ASCVD population: Lp(a)HERITAGE (Nissen et al., Open Heart 2022)Open Heart · October 2022 7
• Lp(a) lowering by alirocumab reduces total cardiovascular events independent of LDL-C: ODYSSEY OUTCOMES (Szarek et al., EHJ 2020)Eur Heart J · November 2020 7
• Elevated Lp(a) and risk of ischaemic stroke, observational and genetic (Langsted et al., JACC 2019)J Am Coll Cardiol · July 2019 7
• NLA scientific statement: use of Lp(a) in clinical practice, a biomarker whose time has come (Wilson et al., J Clin Lipidol 2019)J Clin Lipidol · January 2019 7
• Lp(a) predicts cardiovascular events in Black and White adults alike: ARIC (Virani et al., Circulation 2012)Circulation · January 2012 7
• The mysteries of lipoprotein(a) (Utermann, Science 1989)Science · November 1989 7
• Lp(a) and interleukin-6 are independent, additive predictors of coronary events: MESA and UK Biobank (Bhatia et al., JACC 2025)J Am Coll Cardiol · November 2025 6
• Twelve years of lipoprotein apheresis for Lp(a)-associated progressive ASCVD: Pro(a)LiFe (Klingel et al., Atherosclerosis 2025)Atherosclerosis · November 2025 6
• Lp(a) testing in a large US academic health system: 0.3 percent of adults over ten years (Bhatia et al., JAHA 2023)J Am Heart Assoc · September 2023 6
• Sex differences in Lp(a) levels and associated risk by age: Copenhagen (Simony et al., Atherosclerosis 2022)Atherosclerosis · August 2022 6
• Lp(a) predicts not just new peripheral artery disease and carotid stenosis but their progression to limb loss and stroke, UK Biobank analysis of 460,544 people finds (Circulation 2025)Circulation · July 2025 9
• Lowering Lp(a) and IL-6 signalling together additively cuts coronary disease risk, Mendelian randomisation of 408,687 (Eur J Prev Cardiol 2026)Eur J Prev Cardiol · February 2026 8
• Genetic Lp(a) raises large-artery stroke risk 23% but not small vessel stroke, Mendelian randomisation of 343,681 (J Am Heart Assoc 2026)J Am Heart Assoc · January 2026 8
• Only 1 in 20 young ischemic stroke patients had ever been tested for Lp(a) by 2024, despite testing more than doubling since 2015, 188,305-patient US analysis finds (J Stroke Cerebrovasc Dis 2026)J Stroke Cerebrovasc Dis · December 2025 8
• Impact of Obicetrapib on Major Adverse Cardiovascular Events in High-Risk Patients: A Pooled AnalysisJ Am Coll Cardiol · October 2025 8
• Lp(a) above 125 nmol/L predicts ischaemic stroke in men but not women, and equally across age and ethnicity, UK Biobank analysis of 353,309 finds (Am J Prev Cardiol 2025)Am J Prev Cardiol · June 2025 8
• Lp(a)'s causal effect on MI and large-artery stroke matches across East Asian and European ancestry, Mendelian randomization study finds (Circulation 2025)Circulation · April 2025 8
• Lp(a) in the top quintile nearly doubles stroke/TIA odds and doubles cerebral injury odds in 16,333 Hispanic and Latino adults, HCHS/SOL study finds (Stroke 2025)Stroke · April 2025 8
• High Lp(a) patients with intracranial stenosis get the most benefit from remote ischemic conditioning, RICA trial analysis of 1,286 patients finds (Neurotherapeutics 2025)Neurotherapeutics · March 2025 8
• Elevated Lp(a) triples stroke-recurrence risk in patients under 60, the BIOSIGNAL study of 1,733 acute stroke patients (Eur Heart J 2021)Eur Heart J · June 2021 8
• Lp(a) predicts ischemic stroke risk nearly twice as strongly in Black versus White Americans, the REGARDS study of 30,239 adults (Arterioscler Thromb Vasc Biol 2019)Arterioscler Thromb Vasc Biol · April 2019 8
• Lp(a) above 50 mg/dL confers over 10-fold higher risk of heart attack, stroke or amputation in patients with existing artery disease, the FRENA registry of 1503 patients (Atherosclerosis 2018)Atherosclerosis · July 2018 8
• Comparative associations of LDL-C, Lp(a), hsCRP, and IL-6 with cardiovascular risk: Insights from the UK Biobank and MESAProg Cardiovasc Dis · May 2026 7
• Lipoprotein(a), High-Sensitivity C-Reactive Protein, and Incident ASCVD Risk in Individuals Without Standard Modifiable Risk FactorsEur J Prev Cardiol · April 2026 7
• Lp(a) reduction explains only a small part of IL-6 inhibition's cardiovascular benefit, Mendelian randomisation study (Atherosclerosis 2026)Atherosclerosis · March 2026 7
• Elevated Lp(a) marks a high-risk phenotype in advanced coronary calcification, IVUS study of 292 (Int J Cardiol Cardiovasc Risk Prev 2026)Int J Cardiol Cardiovasc Risk Prev · February 2026 7
• Lp(a) 50 mg/dL or more raises intracranial stenosis odds 4.5-fold in ischemic stroke, cohort of 397 (J Clin Lipidol 2026)J Clin Lipidol · January 2026 7
• Both very low and very high Lp(a) raise stroke recurrence risk in 3,311 diabetic stroke patients, U-shaped pattern from China's national registry finds (Diabetol Metab Syndr 2025)Diabetol Metab Syndr · November 2025 7
• Elevated Lp(a) tracks with vulnerable intracranial plaque features on high-resolution MRI and a 2.65-fold higher stroke recurrence risk (Eur Radiol 2025)Eur Radiol · June 2025 7
• Lp(a)'s coronary risk is amplified in patients with high cholesterol or triglycerides, but not for aortic stenosis or stroke, UK Biobank study of 127,958 finds (Am J Prev Cardiol 2025)Am J Prev Cardiol · May 2025 7
• Elevated Lp(a) nearly triples the odds of significant white matter damage in young stroke patients, 217-patient study finds an AUC of 0.81 (J Neurol 2025)J Neurol · May 2025 7
• Lp(a) above 15 mg/dL raises 1-year MACE risk 68% after stroke or TIA, specifically in atherothrombotic subtype, Japanese cohort of 533 finds (Atherosclerosis 2025)Atherosclerosis · May 2025 7
• Elevated Lp(a) raises stroke recurrence odds by 69% and poor functional outcome odds by over 2-fold, meta-analysis of 17,903 patients finds (J Stroke 2025)J Stroke · May 2025 7
• Elevated Lp(a) more than doubles arterial stroke risk in children and youth, meta-analysis of 9,923 young patients finds (J Cardiovasc Med (Hagerstown) 2025)J Cardiovasc Med (Hagerstown) · April 2025 7
• Combined elevation of Lp(a), hs-CRP and homocysteine triples stroke risk in the Multi-Ethnic Study of Atherosclerosis (Am J Prev Cardiol 2025)Am J Prev Cardiol · December 2024 7
• Meta-analysis of 11,958 stroke patients finds high Lp(a) more than doubles the odds of poor functional recovery, strongest soon after stroke (Eur J Neurol 2024)Eur J Neurol · October 2024 7
• First demonstration that combining Lp(a) with fibrinogen nearly quintuples stroke risk in 8,263 coronary disease patients (Eur J Clin Invest 2024)Eur J Clin Invest · February 2024 7
• Combined elevation of Lp(a) and Lp-PLA2 raises 1-year stroke recurrence risk in 10,675 ischaemic stroke and TIA patients (J Clin Lipidol 2024)J Clin Lipidol · January 2024 7
• Lp(a) above 50 mg/dL raises carotid plaque risk by 30% in a Chinese population distribution study of 411,634 adults (Atherosclerosis 2023)Atherosclerosis · March 2023 7
• Elevated Lp(a) raises ischaemic stroke risk and specifically large-artery atherosclerosis stroke, a meta-analysis of 40,012 people across 41 studies (Sci Rep 2021)Sci Rep · August 2021 7
• Lp(a) is linked to more vulnerable carotid plaque features, with sex-specific patterns, in the Dutch PARISK study of 182 patients (Atherosclerosis 2021)Atherosclerosis · June 2021 7
• Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients With High-Risk Vascular Disease: A Prespecified Secondary Analysis of the ACCELERATE TrialJAMA Cardiol · October 2020 7
• Lp(a) in the highest tertile raises stroke risk by 34% in a prospective cohort of 8500 Chinese adults (Atherosclerosis 2019)Atherosclerosis · July 2019 7
• Association of Lipoprotein(a) With Risk of Recurrent Ischemic Events Following Acute Coronary Syndrome: Analysis of the dal-Outcomes Randomized Clinical TrialJAMA Cardiol · February 2018 7
• Lp(a), not apo(a) size, independently predicts unexplained stroke in young white adults, a case-control study of 255 stroke patients (Atherosclerosis 2016)Atherosclerosis · August 2016 7
• Lp(a) raises ischemic stroke risk by about a third, especially in younger patients, a meta-analysis of 20 studies and 90,904 subjects (Atherosclerosis 2015)Atherosclerosis · August 2015 7
• The highest Lp(a) quartile raises the risk of combined intracranial and extracranial artery narrowing five-fold in stroke patients, a Korean study of 1012 patients (Atherosclerosis 2010)Atherosclerosis · July 2010 7
• Lp(a) more than triples ischemic stroke risk in the elderly, a Greek case-control study of 163 stroke patients and 166 controls (Atherosclerosis 2006)Atherosclerosis · September 2005 7
• Prospective cohorts show no association between serum Lp(a) and incident hemorrhagic stroke (J Stroke Cerebrovasc Dis 2026)J Stroke Cerebrovasc Dis · August 2026 6
• Lp(a) predicts post-stroke cognitive impairment independent of inflammation, 954-patient Chinese registry substudy (Transl Stroke Res 2026)Transl Stroke Res · July 2026 6
• Preoperative Lp(a) of 30 mg/dL or more doubles 1-year stroke risk after intracranial stenting, 405-patient registry (Neurologist 2026)Neurologist · July 2026 6
• Lp(a) of 75 nmol/L or more predicts worse neurological outcome after ischemic stroke, Spanish cohort of 300 (Clin Investig Arterioscler 2026)Clin Investig Arterioscler · May 2026 6
• Lp(a) and inflammation (CAR) jointly predict poor 90-day outcome after stroke in elderly patients, cohort of 732 (Lipids Health Dis 2026)Lipids Health Dis · May 2026 6
• Lp(a) above 31.2 mg/dL raises poor 3-month stroke outcome risk 79%, cohort of 175 (Brain Behav 2026)Brain Behav · May 2026 6
• High Lp(a) predicts worse outcomes but poor discrimination after drug-eluting stent PCI, meta-analysis of 27,618 (J Clin Lipidol 2026)J Clin Lipidol · April 2026 6
• Preoperative Lp(a) of 30 mg/dL or more independently predicts peri-procedural stroke after intracranial stenting (Neurol Res 2026)Neurol Res · March 2026 6
• Lp(a) does not track with carotid thickness or stenosis despite its stroke-risk link, BIOSIGNAL cohort of 1,161 (Lipids Health Dis 2026)Lipids Health Dis · March 2026 6
• Individualised, phenotype-guided dyslipidaemia management for stroke prevention, review covering Lp(a)-lowering agents (Int J Stroke 2026)Int J Stroke · January 2026 6
• A clinical practice review of Lp(a) risk stratification and the emerging lowering agents (Eur J Clin Invest 2026)Eur J Clin Invest · October 2025 6
• Higher Lp(a) and lower ApoA1 mark stroke patients whose ischaemic penumbra is preserved beyond the standard treatment window, case-control and Mendelian randomization study finds (Curr Med Chem 2025)Curr Med Chem · October 2025 6
• Higher Lp(a) independently predicts cognitive impairment after ischaemic stroke, 790-patient Chinese study finds (Br J Hosp Med (Lond) 2025)Br J Hosp Med (Lond) · August 2025 6
• Lp(a) is firmly linked to large-artery atherosclerotic stroke, but its role in other stroke subtypes stays inconsistent, review of pathways and emerging therapies finds (J Clin Med 2025)J Clin Med · April 2025 6
• Elevated Lp(a) predicts periprocedural stroke and later ACS after carotid endarterectomy but not restenosis, systematic review of 1,450 patients finds (J Clin Med 2025)J Clin Med · March 2025 6
• Carrying the CYP2C19 AA genotype alongside elevated Lp(a) raises the odds of poor stroke recovery more than 15-fold (Am J Transl Res 2025)Am J Transl Res · January 2025 6
• Lp(a) above the 90th percentile predicts recurrent ischaemic stroke in 2,029 patients with type 2 diabetes but not in those without it (Diabetes Metab Syndr Obes 2025)Diabetes Metab Syndr Obes · January 2025 6
• Combining Lp-PLA2 with Lp(a) outperforms either marker alone for predicting stroke recurrence in 580 ischaemic stroke patients (J Clin Lab Anal 2024)J Clin Lab Anal · December 2024 6
• Meta-analysis of 1,345 patients finds young stroke patients are 61% more likely to have elevated Lp(a) than age-matched controls (J Stroke Cerebrovasc Dis 2024)J Stroke Cerebrovasc Dis · August 2024 6
• Elevated Lp(a) nearly doubles ischaemic event recurrence after cerebral vascular stenting in 553 patients (J Stroke Cerebrovasc Dis 2024)J Stroke Cerebrovasc Dis · July 2024 6
• Swiss CoRisk cohort externally validates Lp(a) as a marker of large artery atherosclerosis stroke, but only in patients without diabetes (Swiss Med Wkly 2024)Swiss Med Wkly · April 2024 6
• Lipoprotein(a) is positively associated with moyamoya disease in a 1012-patient case-control study (Lipids Health Dis 2024)Lipids Health Dis · January 2024 6
• High Lp(a) (>30 mg/dL) raises ischaemic stroke risk in atrial fibrillation patients across four adjustment models, in 2,258 propensity-matched patients (Int J Gen Med 2024)Int J Gen Med · January 2024 6
• Lp(a) above 117 nmol/L more than doubles ischaemic stroke risk, driven by the large-artery atherosclerosis subtype, in a case-control study of 231 stroke patients (Neurol Neurochir Pol 2024)Neurol Neurochir Pol · January 2024 6
• Lp(a) rises with carotid atherosclerosis severity in 2,018 acute ischaemic stroke patients (Front Neurol 2024)Front Neurol · January 2024 6
• Elevated Lp(a) is linked to a roughly fourfold higher risk of ischaemic stroke and thrombosis in children, though screening guidelines remain inconsistent, a review (Curr Atheroscler Rep 2023)Curr Atheroscler Rep · May 2023 6
• Elevated Lp(a) raises cognitive impairment odds by 62% and stroke-related disability by 46% in secondary prevention ASCVD patients, a systematic review of 61 studies (PLoS One 2023)PLoS One · January 2023 6
• Lp(a) fully expresses by age 2, but guidelines only recommend testing children after stroke, a review of Lp(a) in pediatrics (J Clin Lipidol 2015)J Clin Lipidol · January 2015 6
• Oxidized Lp(a) appears early in endothelial cells while native Lp(a) marks later fibrin deposits, a study of carotid and cerebral artery plaques (Atherosclerosis 2011)Atherosclerosis · January 2011 6
• Lp(a) does not predict ischemic stroke in young women, a case-control study of 110 cases and 216 controls (Atherosclerosis 2000)Atherosclerosis · June 2000 6
• A meta-analysis of 20,678 atrial fibrillation patients finds modestly higher Lp(a) in those with ischaemic stroke, but flags low-certainty evidence (J Clin Med 2025)J Clin Med · November 2025 5
• Systematic review of 26 studies finds Mendelian randomisation but not observational data supports a causal role for Lp(a) in atrial fibrillation (Pol Arch Intern Med 2025)Pol Arch Intern Med · January 2025 5
• Amsterdam UMC case-control study finds Lp(a) above 50 mg/dL is nearly seven times more common in children with ischaemic stroke (Pediatr Blood Cancer 2024)Pediatr Blood Cancer · July 2024 5
• Review notes Lp(a)'s stroke association is well replicated in epidemiology but only marginal in Mendelian randomisation studies (J Int Med Res 2024)J Int Med Res · July 2024 5
• Higher Lp(a) and TG/HDL-C ratio flag unstable carotid plaque in 142 acute ischaemic stroke patients (Brain Behav 2024)Brain Behav · January 2024 5
• Serum Lp(a) >=300 mg/L predicts early neurological deterioration after thrombolysis for acute ischaemic stroke in 236 patients (Int J Gen Med 2024)Int J Gen Med · January 2024 5
• High Lp(a) is associated with greater cerebral white matter hyperintensity burden in 153 stroke and TIA patients (Front Neurol 2024)Front Neurol · January 2024 5
• One in three Ghanaian ischaemic stroke survivors has elevated lipoprotein(a), linked to female sex, diabetes and urban residence (J Neurol Sci 2024)J Neurol Sci · December 2023 5
• Mendelian randomisation confirms Lp(a) drives coronary disease, aortic stenosis, stroke and heart failure regardless of LDL control, a review revisiting two decades of evidence (Circ J 2020)Circ J · April 2020 5
• Emerging apo(a)-targeted therapies could transform Lp(a) management, a review of Lp(a)'s role in preventive cardiology (Curr Opin Cardiol 2019)Curr Opin Cardiol · September 2019 5
• The Lp(a) hypothesis awaits its first clinical trial test, unlike the LDL hypothesis, a review of Lp(a) and cardiovascular disease (Front Biosci (Landmark Ed) 2018)Front Biosci (Landmark Ed) · January 2018 5
• Lp(a) microRNA regulation could hold clues to its role in stroke, a review calling for further research (Cardiovasc Hematol Disord Drug Targets 2017)Cardiovasc Hematol Disord Drug Targets · January 2017 5
• Lipoprotein(a) Levels and Embolic Stroke of Undetermined Source in Patients with Patent Foramen Ovale (J Clin Med 2026)J Clin Med · August 2026 4
• Uric acid and Lp(a) track with neurological damage severity in diabetic patients with penetrating-artery cerebral infarction (Pak J Pharm Sci 2026)Pak J Pharm Sci · January 2026 4
• Review finds Lp(a) is a weaker predictor of cerebral atherosclerosis and stroke than of coronary disease (Wiad Lek 2025)Wiad Lek · January 2025 4
• A 34-year-old man with Lp(a) of 212 mg/dL and stroke saw his level drop 15% with aspirin but not statins, a case report (J Clin Lipidol 2016)J Clin Lipidol · January 2016 4
• Association of lipoprotein(a), oxidized phospholipids and apolipoprotein B100 in acute ischemic stroke cohortAdv Lipoprotein A Res · January 2026 3