Epidemiology
Elevated Lp(a) nearly doubles ischaemic event recurrence after cerebral vascular stenting in 553 patients (J Stroke Cerebrovasc Dis 2024)
Original title: Correlation between lipoprotein(a) and recurrent ischemic events post-cerebral vascular stent implantation
In 553 patients who underwent intracranial or extracranial artery stent implantation, 107 (19.3%) experienced a recurrent ischaemic outcome during follow-up. Recurrence was more common in patients with elevated Lp(a) (above 30 mg/dL) than those without (25.4% vs. 16.4%, chi-squared = 6.343, p = 0.012). Patients with elevated Lp(a) were 1.811 times more likely to experience a recurrent ischaemic event, and each 1 mg/dL increase in Lp(a) raised recurrence risk 1.008-fold. Male sex, prior coronary heart disease, low albumin, elevated VLDL cholesterol, and poorly controlled blood pressure or blood glucose were also associated with higher recurrence risk. A nomogram-based prediction model was developed incorporating these factors. Elevated Lp(a) is a significant, independent risk factor for recurrent ischaemic events after intracranial or extracranial artery stenting, supporting its inclusion in post-procedural risk assessment.
Original abstract
Background And Aim: The association of Lipoprotein(a) (Lp[a]) with recurrent ischemic events in stented patients remains uncertain. So, this research aimed to investigate the impact of elevated Lp(a) levels on the occurrence of ischemic events in this specific patient population.
Methods: Totally 553 patients who underwent intracranial or extracranial artery stent implantation were included. Baseline data were collected and postoperative ischemic outcomes were followed up. Cox regression analysis was used to investigate the association between Lp(a) and outcomes, while accounting for confounding factors. Finally, we established prediction models based on nomogram.
Results: Of total 553 patients, a number of 107 (19.3%) experienced outcomes. These included 46 cases (25.4%) in group with elevated Lp(a) levels (>30 mg/dL) and 61 cases (16.4%) in non-elevated group (χ2=6.343, p=0.012). The group with elevated Lp(a) was 1.811 times more likely to experience ischemic events than the non-elevated group, each 1 mg/dL increase in Lp(a) resulted in a 1.008-fold increase in the recurrence rate of ischemic events. In addition, sex (male), previous history of coronary heart disease, decreased albumin, elevated very low density lipoprotein cholesterol and poorly controlled risk factors (including blood pressure and blood sugar) were also associated with a high risk of recurrent ischemic events after stent implantation.
Conclusion: Lp(a) elevation was a significant risk factor for ischemic events in symptomatic patients who underwent intracranial or extracranial artery stenting.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.