Epidemiology
Lipoprotein(a) is positively associated with moyamoya disease in a 1012-patient case-control study (Lipids Health Dis 2024)
Original title: High lipoprotein(a) concentration is associated with moyamoya disease
In a propensity-matched case-control study of 1012 patients with moyamoya disease (MMD) and 2024 controls from a single Chinese hospital, patients with MMD had higher median Lp(a) than controls (18.5 vs 14.9 mg/dL, P<0.001). Elevated Lp(a) was independently associated with MMD across three regression models adjusted for cardiometabolic and inflammatory covariates, with odds ratios of 1.613, 1.598 and 1.661 (all P<0.001), independent of age, sex or hypertension. The findings identify Lp(a) as a candidate risk marker for this rare cerebrovascular disease of unclear aetiology, though the single-centre retrospective design limits generalisability.
Original abstract
Background: Moyamoya disease (MMD) has attracted the attention of scholars because of its rarity and unknown etiology.
Methods: Data for this study were sourced from the Second Affiliated Hospital of Nanchang University. Regression analyses were conducted to examine the association in Lipoprotein [Lp(a)] and MMD. R and IBM SPSS were conducted.
Results: A cohort comprising 1012 MMD patients and 2024 controls was established through the propensity score matching method. Compared with controls, MMD patients showed higher median Lp(a) concentrations [18.5 (9.6-37.8) mg/dL vs. 14.9 (7.8-30.5) mg/dL, P < 0.001]. The odds ratios and 95% confidence intervals for Lp(a) were calculated in three models: unadjusted model, model 1 (adjusted for body mass index and systolic blood pressure), and model 2 (adjusted for model 1 plus triglyceride, C-reactive protein, homocysteine, and low-density lipoprotein cholesterol). Results were [1.613 (1.299-2.002), P < 0.001], [1.598 (1.286-1.986), P < 0.001], and [1.661 (1.330-2.074), P < 0.001], respectively. Furthermore, age, sex, or hypertension status had nothing to do with this relationship.
Conclusions: Positive relationship exists between Lp(a) and MMD.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.