Epidemiology
Serum Lp(a) >=300 mg/L predicts early neurological deterioration after thrombolysis for acute ischaemic stroke in 236 patients (Int J Gen Med 2024)
Original title: Serum Lipoprotein(a) as Predictive Factor for Early Neurological Deterioration of Acute Ischemic Stroke After Thrombolysis
In a study of 236 patients with acute ischaemic stroke treated with thrombolysis, early neurological deterioration (END, an NIHSS increase of at least 2 points within 48 hours) was more common in those with higher Lp(a) (high-Lp(a) group 38.3% vs 22.2% without END, P<0.005). In multivariate analysis, Lp(a) >=300 mg/L was an independent risk factor for END (OR 3.154, 95% CI 1.067-9.322, P=0.038). The findings suggest serum Lp(a) measured on admission could help identify stroke patients at higher risk of early deterioration after thrombolysis, though confirmation in larger, multicentre cohorts is needed.
Original abstract
Objective: This study aimed to explore the relationship between serum lipoprotein(a) (LP(a)) levels and early neurological deterioration (END) in patients with acute ischemic stroke (AIS) after thrombolysis.
Methods: In total, 236 patients with AIS after thrombolysis were enrolled in this study. Serum LP(a) levels were measured on admission after thrombolysis. END was defined as an increase of at least two points in the NIHSS score within 48 hours after thrombolysis. Binary logistic regression analysis was used to assess the association between serum LP(a) levels and END.
Results: Overall, patients with END had higher LP(a) than those without END (high LP(a): 38.3% vs 22.2%, intermediate LP(a): 40.3% vs 41.8%, low LP(a): 21.3% vs 36.0%, p<0.005). In the multivariate analysis, high LP(a) (defined as LP(a) level≥ 300 mg/L) was an independent risk factor for END post-thrombolysis (OR=3.154, 95% CI=1.067-9.322, p=0.038).
Conclusion: Our findings demonstrated that LP(a) was an independent risk factor for END post-thrombolysis and that LP(a) level≥ 300 mg/L could be associated with END post-thrombolysis in this study population.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.