History 9 items

Trials, agents, guidance

• Guideline EAS consensus panel: Lp(a) as a cardiovascular risk factor, current status (2010)Historical (replaced by the 2022 statement)

Studies

• Apo(a) is homologous to plasminogen: the cDNA sequence (McLean et al., Nature 1987)Nature · November 1987 9
• Berg describes the Lp system, the first report of lipoprotein(a) (1963)Acta Pathol Microbiol Scand · January 1963 8
• The mysteries of lipoprotein(a) (Utermann, Science 1989)Science · November 1989 7
• Lp(a) was discovered in 1963 and its size heterogeneity explained decades later by Gerd Utermann, a historical appraisal (J Lipid Res 2017)J Lipid Res · November 2016 6
• Lp(a) levels above 300 mg/L significantly raise cardiovascular risk, a review of Lp(a) structure, metabolism and emerging therapies (J Lipids 2020)J Lipids · January 2020 5
• Lp(a) is shifting from a mere biomarker to a potential therapeutic target, a review of the evidence since its 1963 discovery (J Atheroscler Thromb 2019)J Atheroscler Thromb · April 2019 5

Timeline

• Causality established: Clarke (NEJM) and Kamstrup (JAMA) Mendelian randomisation studies24 December 2009
• Kåre Berg describes the Lp system1 January 1963