Epidemiology
In patients referred for coronary angiography, elevated Lp(a) tracks with premature and multivessel coronary disease but not hypertension or obesity (Herz 2024)
Original title: Association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography
In this retrospective study of patients hospitalised for coronary angiography, stratified into four Lp(a) groups, elevated Lp(a) showed no significant relationship with hypertension, obesity, smoking, hyperuricaemia, or family history of diabetes or hyperlipidaemia. However, elevated Lp(a) was associated with higher total cholesterol and LDL cholesterol, and with increased rates of diabetes, premature coronary artery disease (CAD), multivessel disease, and need for percutaneous coronary intervention. Multivariable logistic regression confirmed elevated Lp(a) as an independent factor for high total cholesterol, high LDL-C, diabetes, CAD, premature CAD, multivessel disease, and PCI. The findings support Lp(a) as a marker specifically linked to coronary disease burden and severity, distinct from traditional metabolic risk factors like hypertension and obesity, in patients undergoing angiographic evaluation.
Original abstract
Objective: Many previous studies reported the relationship between lipoprotein(a) and cardiovascular disease, but the conclusions were controversial. The aim of our study was to retrospectively investigate the association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.
Methods: We collected and compared clinical information of patients hospitalized for coronary angiography. Multivariable hierarchical logistic regression was used to evaluate the association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.
Results: There were no significant differences in gender, hypertension, APOA1, smoking, hyperuricemia, obesity, acute myocardial infarction (AMI), cardiac insufficiency, family history of diabetes, or family history of hyperlipidemia among the four groups of lipoprotein(a). Elevated lipoprotein(a) does not increase the risk of hypertriglyceridemia, while elevated lipoprotein(a) increases the risk of high total cholesterol and high low-density lipoprotein cholesterol (LDL-c). Elevated lipoprotein(a) increases the risk of diabetes and premature coronary artery disease (CAD). Elevated lipoprotein(a) increases the incidence of CAD, multivessel lesions, and percutaneous coronary intervention (PCI). Multivariate logistic regression analysis further showed that elevated lipoprotein(a) increases the incidence of high total cholesterol, high LDL‑c, diabetes, CAD, premature CAD, multivessel lesions, and PCI.
Conclusion: The findings indicated that elevated lipoprotein(a) had no obvious relationship with hypertension and obesity. Elevated lipoprotein(a) increases the risk of high total cholesterol, high LDL‑c, and premature CAD, and increases the occurrence and severity of coronary heart disease.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.