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Thirty frequent questions on the 2022 EAS Lp(a) consensus, answered (Kronenberg, Mora, Stroes et al., Atherosclerosis 2023)
Original title: Frequent questions and responses on the 2022 lipoprotein(a) consensus statement of the European Atherosclerosis Society
The consensus authors answer the questions that came back from practice: epidemiology, contribution to risk, the new lifetime-risk calculator that adds Lp(a) to global risk, measurement and units, how to manage risk factors when the Lp(a) itself cannot yet be lowered, and the existing therapies. Written against the reflex 'why measure what I cannot treat'.
Original abstract
In 2022, the European Atherosclerosis Society (EAS) published a new consensus statement on lipoprotein(a) [Lp(a)], summarizing current knowledge about its causal association with atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. One of the novelties of this statement is a new risk calculator showing how Lp(a) influences lifetime risk for ASCVD and that global risk may be underestimated substantially in individuals with high or very high Lp(a) concentration. The statement also provides practical advice on how knowledge about Lp(a) concentration can be used to modulate risk factor management, given that specific and highly effective mRNA-targeted Lp(a)-lowering therapies are still in clinical development. This advice counters the attitude: "Why should I measure Lp(a) if I can't lower it?". Subsequent to publication, questions have arisen relating to how the recommendations of this statement impact everyday clinical practice and ASCVD management. This review addresses 30 of the most frequently asked questions about Lp(a) epidemiology, its contribution to cardiovascular risk, Lp(a) measurement, risk factor management and existing therapeutic options.
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Summary written by lp-a.org from the published abstract; figures as published. Page updated 17 August 2026. Methods.