Mechanisms
A rare case links elevated Lp(a) to aortic thrombosis in a non-aneurysmal aorta for the first time, a case report (Vasc Endovascular Surg 2016)
Original title: A Unique Case of Aortic Thrombosis With Elevated Lipoprotein(a)
This case report by Ostertag-Hill, Titus and Skeik describes a patient with aortic thrombosis causing acute lower limb ischemia, elevated Lp(a), and other comorbidities. Aortic thrombosis is a rare condition that can arise from atherosclerosis, aneurysm, thrombophilia, vasculitis, trauma or malignancy, with management including surgical thromboembolectomy or conservative anticoagulation. Based on their literature review, the authors state this is the first report establishing a connection between elevated Lp(a) and aortic thrombosis occurring in a non-aneurysmal aorta.
Original abstract
Aortic thrombosis is a rare condition that can be caused by atherosclerosis, aneurysms, thrombophilia, vasculitis, trauma, and malignancy. Symptoms vary based on thrombus size and site of embolization. It can lead to devastating complications including acute limb ischemia, myocardial infarction, stroke, and other target organ ischemia. Diagnosis is based on clinical presentation, imaging findings, and relevant laboratory work-up. Although not well defined, management for aortic thrombosis includes surgical intervention, such as thromboembolectomy, and conservative measures, such as anticoagulation. Here, we present a unique case of aortic thrombosis causing acute lower limb ischemia with elevated lipoprotein(a) and other comorbidities. Based on our literature review, our article is the first to establish the connection between elevated lipoprotein(a) and aortic thrombosis in the nonaneurysmal aorta.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.