Olpasiran 42 items
Trials, agents, guidance
- Agent Olpasiran (AMG 890)
- Trial OCEAN(a)-Outcomes
- Trial OCEAN(a)-DOSE
Studies
- OCEAN(a)-DOSE: olpasiran lowers Lp(a) by more than 95 percent in patients with ASCVD (O'Donoghue et al., NEJM 2022)
- Olpasiran, a GalNAc-conjugated siRNA against LPA: preclinical development and phase 1 (Koren et al., Nat Med 2022)
- Olpasiran lowers oxidised phospholipids on apoB by about 90 percent without moving hs-CRP or IL-6: OCEAN(a)-DOSE (Rosenson et al., JAMA Cardiol 2025)
- After stopping olpasiran, Lp(a) stays 40 to 50 percent below baseline for nearly a year: OCEAN(a)-DOSE extension (O'Donoghue et al., JACC 2024)
- Olpasiran and apolipoprotein B particles: what siRNA-mediated Lp(a) removal does to the apoB pool (Zimerman et al., JAMA Cardiol 2025)
- Lp(a) and its significance in cardiovascular disease: a review (Duarte Lau and Giugliano, JAMA Cardiol 2022)
- Olpasiran tops a network meta-analysis of 51 trials (17,810 patients) ranking Lp(a)-lowering therapies against PCSK9 inhibitors (Diabetes Obes Metab 2026)
- Olpasiran leads a network meta-analysis of 25 trials (7,715 patients) ranking every Lp(a)-lowering agent (Pharmacol Res 2026)
- Olpasiran ranks as the most effective Lp(a)-lowering therapy, network meta-analysis of 1,432 patients (Front Cardiovasc Med 2026)
- Five late-stage RNA and small-molecule Lp(a) therapies near approval, from pelacarsen to muvalaplin (Curr Atheroscler Rep 2026)
- From apheresis to CRISPR: review maps every Lp(a)-lowering therapy in development (Curr Atheroscler Rep 2026)
- Olpasiran and pelacarsen cut Lp(a) by 85-90%, with phase 3 outcome trials testing whether this prevents aortic stenosis progression (Int J Mol Sci 2023)
- Gene-silencing drugs cut Lp(a) by 70-90% and LDL-C by over 30%, positioning PCSK9 and Lp(a) as the leading targets for RNA-based cardiovascular therapy, a review (Clin Ther 2023)
- About 20% of people carry elevated Lp(a), and phase 3 outcome trials of pelacarsen and olpasiran are now testing whether lowering it reduces cardiovascular events (Annu Rev Pharmacol Toxicol 2024)
- Every RNA-based Lp(a) drug tested lowers it by more than 90%, a systematic assessment of 22 trials of pelacarsen, olpasiran, SLN360 and LY3819469 (J Cardiovasc Pharmacol 2023)
- Elevated Lp(a) (>=200 nmol/L) raises cardiovascular event risk by 33% in a cohort mirroring the OCEAN(a)-Outcomes trial population, 3,142 patients (Eur Heart J Open 2023)
- Trial design challenges for Lp(a)-lowering therapies take center stage as pelacarsen and olpasiran enter phase 3 outcomes trials, a JACC Focus Seminar (J Am Coll Cardiol 2023)
- Pelacarsen and olpasiran achieve up to 90% Lp(a) reductions, positioning routine Lp(a) testing as clinically essential, a review (Curr Opin Lipidol 2023)
- Olpasiran cuts Lp(a) by up to 99% with similar effect in Japanese and non-Japanese subjects, a phase 1 dose-finding trial (Clin Ther 2022)
- The OCEAN(a)-DOSE trial enrolls 281 patients to find olpasiran optimal dose ahead of a cardiovascular outcomes trial (Am Heart J 2022)
- Olpasiran achieves more than 95% Lp(a) reduction in OCEAN(a)-DOSE, review of its pharmacology and trial data (Cardiovasc Hematol Disord Drug Targets 2026)
- Individualised, phenotype-guided dyslipidaemia management for stroke prevention, review covering Lp(a)-lowering agents (Int J Stroke 2026)
- Structural model separates functional LPA gene variants from bystanders shaping Lp(a) and CAD risk, review (Prog Lipid Res 2026)
- Lp(a) biology and the full emerging-therapy pipeline, review spanning ASOs to CRISPR and obicetrapib (Cardiovasc Drugs Ther 2026)
- Olpasiran and pelacarsen could be cost-effective at AU$1867 and AU$984 per year for secondary prevention of coronary heart disease, an early Australian health technology assessment (J Clin Lipidol 2024)
- New ASO and siRNA drugs cut Lp(a) by up to 98%, far beyond what existing lipid-lowering therapies achieve, a review argues we are not yet ready to treat Lp(a) (Curr Atheroscler Rep 2023)
- Traditional Lp(a) drugs barely reach 50% reduction while new RNA-interfering agents may exceed 95%, a review of emerging pharmacotherapies (Int J Mol Sci 2023)
- Pelacarsen, olpasiran and SLN360 lower Lp(a) by up to 90%, with pelacarsen phase 3 outcome trial due in 2024, a review (Curr Atheroscler Rep 2022)
- Lipoprotein apheresis: From familial hypercholesterolemia and elevated lipoprotein(a) to emerging roles in peripheral arterial and renal disease
- Molecular Mechanisms and Therapeutic Targets of RNA-Based and Traditional Lipid-Lowering Agents in Residual Cardiovascular Risk: A Scoping Review of Key Directions Towards Future Perspectives
- Lp(a) rises as kidney function declines, adding unaddressed cardiovascular risk in CKD, review (Cardiorenal Med 2026)
- Lp(a)-targeted RNA therapies cut levels by 80-100%, but outcome data are still pending, Korean review (Korean Circ J 2026)
- OCEAN(a)-DOSE shows dose-dependent Lp(a) lowering with olpasiran every 12 weeks, part of a broader review of siRNA therapies for dyslipidaemia (Curr Atheroscler Rep 2023)
- About 20% of Europeans have elevated Lp(a) that current lipid drugs cannot adequately lower, but four RNA-based agents in trials could close that gap, a review (Pharmaceuticals 2022)
- Pelacarsen, olpasiran and SLN360 headline a wave of recent Lp(a)-lowering RNA trials, with outcomes data the next frontier, a review (Curr Opin Lipidol 2022)
Video and podcasts