Testing
In 67 statin-naive adults, Lp(a) is independent of the standard lipid profile but rises with age, reinforcing the case for dedicated screening (Wiad Lek 2025)
Original title: Beyond traditional lipid markers: why lipoprotein(a) screening matters
In this study of 67 statin-naive adults without established atherosclerotic cardiovascular disease, Lp(a) measured by nephelometry showed no statistically significant correlation with traditional lipid profile parameters in either study group (p > 0.05), confirming that Lp(a) carries information independent of the standard lipid panel. A moderate, statistically reliable direct correlation was found between Lp(a) and age in one group (R = 0.46, p = 0.04). The authors argue that because Lp(a) contributes to cardiovascular risk independently of other lipid parameters, and because Lp(a) concentrations tend to rise after menopause, routine Lp(a) screening is warranted in clinical practice, with particular attention to monitoring women through the peri- and postmenopausal period.
Original abstract
Objective: Aim: To assess the correlation between lipoprotein(a) levels and traditional lipid profile markers in statin-naive men and women without established atherosclerotic cardiovascular disease.
Patients And Methods: Materials and Methods: Sixty-seven statin-naive adult patients without a prior history of established atherosclerotic cardiovascular disease were included in the study. Lipoprotein(a) levels were determined using nephelometry in all patients.
Results: Results: According to the results of the correlation analysis, it was found that there is no statistically significant correlation between lipoprotein(a) level and traditional parametres of lipid profile in both groups (p>0.05). Reliable direct correlation of moderate strength was observed between lipoprotein(a) and age in the group A (R=0.46, p=0.04).
Conclusion: Conclusions: Elevated lipoprotein(a) levels, independent of other lipid profile parameters, can significantly contribute to cardiovascular risk, emphasizing the importance of routine lipoprotein(a) screening in clinical practice. It is particularly noteworthy that lipoprotein(a) concentrations tend to increase after menopause, potentially placing postmenopausal women at an elevated risk for cardiovascular events. Consequently, it is imperative to monitor lipoprotein(a) levels in females, especially during the peri-menopausal and postmenopausal stages, to more accurately assess and manage cardiovascular risk in this population.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.