Mechanisms
Lp(a) above 450 mg/L predicts earlier restenosis after angioplasty, especially combined with anticardiolipin antibodies, a study of 167 patients (Atherosclerosis 2001)
Original title: Lipoprotein (a) and anticardiolipin antibodies are risk factors for clinically relevant restenosis after elective balloon percutaneous transluminal coronary angioplasty
This study measured Lp(a), fibrinolytic parameters, and anticardiolipin antibodies (aCL) in 167 patients undergoing elective balloon angioplasty without stenting, to assess their association with clinical restenosis. Over follow-up, 29 patients developed clinically relevant restenosis. Lp(a) was significantly higher in patients with restenosis than without (P<0.05), with earlier restenosis seen in those with Lp(a) above 450 mg/L; Kaplan-Meier analysis showed even earlier restenosis in patients with baseline Lp(a) above 300 mg/L combined with aCL positivity. The findings show high Lp(a) contributes to clinical restenosis after balloon angioplasty without stenting, an effect accelerated by concurrent anticardiolipin antibody positivity.
Original abstract
Recent reports have shown the importance of new risk factors for cardiovascular disease. We investigated the relationship between Lp(a), fibrinolytic parameters and anticardiolipin antibodies (aCL) and the occurrence of clinical recurrence owing to restenosis after elective balloon percutaneous transluminal coronary angioplasty (PTCA) without stenting. In 167 patients, undergoing PTCA, Lp(a) plasma levels, aCL, euglobulin lysis time (ELT), plasminogen activator inhibitor-1 (PAI-1) activity and tissue-type plasminogen activator (t-PA) plasma levels were evaluated before the procedure. During follow-up 29 patients underwent clinical recurrence due to restenosis. Lp(a) levels were significantly higher in patients with restenosis in comparison to those without (P<0.05); an earlier restenosis was observed in patients with Lp(a) values >450 mg/L. Kaplan-Meier survival estimate showed an earlier occurrence of restenosis in patients with base-line Lp(a)>300 mg/l associated with aCL positivity. High Lp(a) plasma levels play a role in the occurrence of clinical recurrence due to restenosis after elective balloon PTCA without stenting; the association with aCL accelerates the development of restenosis.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.