Genetics
LPA risk alleles rs3798220 and rs10455872 raise coronary disease odds up to 75%, meta-analysis of 55,647 (Am J Med Sci 2026)
Original title: The Lipoprotein(a) rs3798220 and rs10455872 polymorphisms and coronary heart disease: a meta-analysis of 55,647 participants
Meta-analysis pooling genetic association studies (55,647 participants) testing LPA polymorphisms rs3798220 and rs10455872 for association with coronary heart disease (CHD). rs3798220 was significantly associated with CHD across allelic (OR 1.488), recessive (OR 1.543), dominant (OR 1.534), homozygous (OR 1.544), heterozygous (OR 1.498) and additive (OR 1.531) genetic models. rs10455872 was similarly associated under allelic (OR 1.607), dominant (OR 1.751), heterozygous (OR 1.723) and additive (OR 1.686) models. The authors conclude both LPA polymorphisms are significantly associated with increased CHD risk, with carriers of the rs3798220-C or rs10455872-G alleles at higher risk than carriers of the alternate alleles.
Original abstract
Background/Aims: The Lipoprotein(a) (LPA) rs3798220 and rs10455872 polymorphisms have been indicated to be involved with the coronary heart disease (CHD) susceptibility. However, there are still differences between the individual studies.
Methods: To explore the correlation of LPA gene rs3798220 and rs10455872 polymorphisms and CHD, the current meta-analysis was performed. The random or fixed effect genetic models were used to calculate the pooled odds ratios (ORs) and their corresponding 95 % confidence intervals (CI).
Results: A significant association was found between LPA rs3798220 polymorphism and CHD under allelic (OR: 1.488), recessive (OR: 1.543), dominant (OR: 1.534), homozygous (OR: 1.544), heterozygous (OR: 1.498) and additive genetic models (OR: 1.531). There was also a significant association between LPA rs10455872 polymorphism and CHD under allelic (OR: 1.607), dominant (OR: 1.751), heterozygous (OR: 1.723) and additive genetic models (OR: 1.686).
Conclusions: LPA rs3798220 and rs10455872 polymorphisms were significantly associated with increased CAD risk. The persons carrying C allele of LPA rs3798220 and G allele of LPA rs10455872 polymorphisms might have higher CHD risk than the T allele of rs3798220 or A allele of rs10455872 carriers.
Summary written by lp-a.org from the published abstract; figures as published. Page updated 17 August 2026. Methods.