Aortic stenosis
From Kare Berg 1963 discovery to today targeted drugs, a practising clinician guide to Lp(a) (J Clin Med 2022)
Original title: Lipoprotein(a): Insights for the Practicing Clinician
This review traces Lp(a) from its discovery by Kare Berg in 1963 through decades of population-based evidence linking elevated Lp(a) to cardiovascular disease, including data from the Copenhagen City Heart and ASTRONOMER studies establishing its link to calcific aortic valve stenosis incidence and progression. The authors note growing clinical interest in Lp(a), driven partly by new emerging therapies that specifically lower it, and highlight that several international guidelines have been updated to recommend Lp(a) testing in specific population groups. The review aims to give practising clinicians a practical understanding of Lp(a) role in cardiovascular disease and the potential of novel Lp(a)-lowering therapies.
Original abstract
Following the discovery of the Lipoprotein(a) (Lp(a)) molecule by Kare Berg in 1963, many physiological and pathological properties of this particle remain to be fully understood. Multiple population-based studies have demonstrated a correlation between elevated Lp(a) levels and the incidence of cardiovascular disease. Data extrapolated from the Copenhagen City Heart and ASTRONOMER studies also demonstrated the link between Lp(a) levels and the incidence and rate of progression of calcific aortic stenosis. Interest in Lp(a) has increased in recent years, partly due to new emerging therapies that can specifically reduce serum Lp(a) concentrations. Given the strong correlation between Lp(a) and CV disease from epidemiological studies, several international guidelines have also been updated to advocate Lp(a) testing in specific population groups. This review aims to highlight the importance of the role of Lp(a) in cardiovascular disease and discusses the potential of novel therapies in patients with elevated Lp(a) levels.
aortic stenosisguidelinestesting
Summary written by lp-a.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.